Nutritional zinc plays a pivotal role in bone health and osteoporosis prevention

Bone homeostasis is maintained through a delicate balance between osteoblastic bone formation and osteoclastic bone resorption [1, 2]. Bone mass is reduced by decrease in osteoblastic bone formation and increase in osteoclastic bone resorption. Numerous pathological processes have the capacity to disrupt this equilibrium leading to conditions where the rate of bone resorption outpaces the rate of bone formation. Osteoporosis is induced with decrease in bone mass. The most dramatic expression of osteoporosis is represented by fractures of the proximal femur for which the number increases as the population ages [3, 4]. Osteoporosis is characterized by reduced bone strength and an increased risk for lowtrauma fractures. Bone mass is dramatically reduced after menopause, which depresses the secretion of ovarian hormone (estrogen) in women [5]. Deficiency of estrogen advances osteoclastic bone resorption. This is very important as a primary osteoporosis. Postmenopausal osteoporosis, a consequence of ovarian hormone deficiency, is the archetypal osteoporotic condition in women after menopause and leads to bone destruction through complex and diverse metabolic and biochemical changes.About 40% of women in developed countries will experience an osteoporosis-related fracture in the course of their lifetime, with men experiencing approximately one-third to one-half the risk of women. According to a recent World Health Organization report, osteoporosis has become a global health problem with a disease incidence and mortality rate similar to that of